AnniZ Lab
Uncovering Diverse Microbial Mechanisms via AI
Our Research:
One Postdoc Position Available!Requirements
One PhD Position Available!Requirements
What to expect as our teammate:
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Dr Anni Zhang, Assis Prof at NTU |
Highlighted Discoveries
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Case 1 of 6:
Sequence aligners use fixed-size k-mers in their algorithms, with the choice of k-mer size significantly impacting alignment quality. Our tool, Mapper, overcomes this by dynamically incorporating k-mers of various sizes (x-mers).
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Case 2 of 6:
Gut microbiomes are actively adapting in healthy human subjects through accumulating beneficial mutations in carbohydrate transport regulators.
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Case 3 of 6:
Gut microbiomes share CRISPR systems through horizontal gene transfer to update their phage defense.
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Case 4 of 6:
A novel algorithm for genetic variant identification that is 9x faster than existing tools, while producing fewer false positives and false negatives.
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Case 5 of 6:
Antibiotic resistance genes (ARGs) are everywhere, but most high-risk ARGs (Rank I, red bars) are only present in human-associated environments but not in natural environments.
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Case 6 of 6:
Antibiotic resistance genes are highly prevalent (red and blue dots) in almost all bacterial genomes. Specifically, ARGs in Gammaproteobacteria (red dots) are spreading by horizontal gene transfer via class 1 integrons (i.e. intI1).
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